The shortcut strategy for beta thalassemia prevention
نویسندگان
چکیده
منابع مشابه
The prevention of thalassemia.
The thalassemias are among the most common inherited diseases worldwide, affecting individuals originating from the Mediterranean area, Middle East, Transcaucasia, Central Asia, Indian subcontinent, and Southeast Asia. As the diseases require long-term care, prevention of the homozygous state constitutes a major armament in the management. This article discusses the major prevention programs th...
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Introduction: Beta thalassemia major is the most common genetic disease in the world. The most common areas of this disease in the world are known as the Thalassemia Belt, which also includes Iran. Kerman province (and especially south of Kerman) ranks first in Iran in terms of the prevalence of thalassemia carriers. Hence, the present study was conducted to investigate the causes of thala...
متن کاملThalassemia in SouthEast Asia: problems and strategy for prevention and control.
In Southeast Asia alpha-thalassemia, beta-thalassemia, hemoglobin (Hb) E and Hb Constant Spring are prevalent. The gene frequencies of alpha-thalassemia reach 30-40% in Northern Thailand and Laos. beta-Thalassemia gene frequencies vary between 1 and 9%. Hb E is the hallmark of Southeast Asia attaining a frequency of 50-60% at the junction of Thailand, Laos, and Cambodia. Hb Constant Spring gene...
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Globally, β-Thalassemia Major (β-TM) is the most commonly inherited hemolytic anemia, with a high incidence rate in Southeast Asia, the Middle East and Mediterranean countries. Patients with β-TM require lifelong adherence to their distressing treatment regimens, including regular blood transfusions and daily chelation therapy.
متن کاملThe compound state: Hb S/beta-thalassemia☆
Sickle cell disease (SCD) results from a single amino acid substitution in the gene encoding the -globin subunit ( 6Glu > Val) that produces the abnormal hemoglobin (Hb) named Hb S. SCD has different genotypes with substantial variations in presentation and clinical course (Table 1).1,2 The combination of the sickle cell mutation and beta-thalassemia ( -Thal) mutation gives rise to a compound h...
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ژورنال
عنوان ژورنال: Hematology Reports
سال: 2018
ISSN: 2038-8330,2038-8322
DOI: 10.4081/hr.2018.7530